A new wave and a new booster? - by Eric Topol

A new wave and a new booster? - by Eric Topol

I would recommend the 2nd booster if you are more than 4-6 months from your 3rd shot, you are age 50+, you tolerated the previous shots well, and you are concerned about the BA.2 wave where you live, or that it’s getting legs as you are trying to decide. Or if you are traveling or have plans that would put you at increased risk.

It can certainly be deferred, but the question is when is the right time, and whether an Omicron-specific vaccine will have any advantage over a 2nd booster directed at the original strain. The data from 2 animal models (macaques and mouse models) suggests there may not be advantage of the Omicron-specific vaccine but that may not correlate with its effect in people. From my discussions with FDA, it is not likely the Omicron-specific vaccine will be available before late May or June. So you can factor that uncertain added benefit and timeline into your decision.

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Vaccine scientists have been chasing variants. Now, they’re seeking a universal coronavirus vaccine.

“I worry about chasing variants, because there’s always going to be a new variant,” said Drew Weissman, a vaccine pioneer and immunologist at the University of Pennsylvania Perelman School of Medicine who is working on a pan-coronavirus vaccine. “Right now, every six months they pop up, but they’re going to pop up until the world is vaccinated.”

Genomic Surveillance for SARS-CoV-2 Variants: Predominance of the Delta (B.1.617.2) and Omicron (B.1.1.529) Variants — United States, June 2021–January 2022

Genomic Surveillance by the CDC: What are the implications for public health practice? The dynamic landscape of SARS-CoV-2 variants in 2021, including Delta- and Omicron-driven resurgences of SARS-CoV-2 transmission across the United States, underscores the importance of robust genomic surveillance efforts to inform public health planning and practice.

So I had Covid last week, from 1/31 to 2/7.  I was really tired the first three days, then felt much better.  I'm so glad I caught the Omicron version of the virus, and that I had good vitamin D levels, two vaccinations and a full booster of the Moderna.  My only accomplishment that week was drinking a lot of La Croix mixed with orange juice and watching the fifth season of The Magicians.

COVID-19: an Endemic Doesn't Mean "harmless"

COVID-19: an Endemic doesn't mean "harmless"

In other words, a disease can be endemic and both widespread and deadly. Malaria killed more than 600,000 people in 2020. Ten million fell ill with tuberculosis that same year and 1.5 million died. Endemic certainly does not mean that evolution has somehow tamed a pathogen so that life simply returns to ‘normal’.

New version of omicron reported dubbed "stealth omicron"

New version of omicron reported dubbed "stealth omicron":The UK Health Agency reported cases of BA.2 have been detected in 40 countries and was first reported in the Philippines. It is the dominant form of the virus in Denmark.

Scientists say there is still much to learn about the new version. As of right now, there is “insufficient” evidence that it causes more severe illness or is more contagious than the original omicron variant.

Opinion | Omicron Is Not the Final Variant - The New York Times

Opinion | Omicron Is Not the Final Variant - The New York Times:

The world got lucky with Omicron. It’s unimaginable what would have happened if that highly contagious variant had caused disease as severe as Delta has. We may not be so lucky the next time. The world cannot afford to be so unprepared ever again.

Transcript: Ezra Klein Interviews Zeynep Tufekci - The New York Times

Transcript: Ezra Klein Interviews Zeynep Tufekci - The New York Times

Tufekci is so smart.  I desperately need to listen to this.

And here’s the thing, it is purely luck that this one is less severe because, contrary to popular belief, viruses don’t evolve to be milder. We gain immunity to them, for sure, as we get exposed, but they just want to transmit, they don’t care if you eventually die as long as they transmit through you.

So the fact that we got a very contagious variant that happens to be milder — and I’m not saying it’s great. I’m just saying it could have been much worse — is pure luck, evolution luck. So that’s what I think we know right now after six weeks, eight weeks, which is pretty amazing.