Thursday, February 25, 2021
Like the South African variant, the Brazilian variant does have the mutation that makes it more infectious, and it also has the E484K mutation
The Immune Escape Strain
“This made the hair on my neck stand up,” Brooks said. Like the South African variant, the Brazilian variant does have the mutation that makes it more infectious, and it also has the E484K mutation, which raises the unsettling possibility that “it could possibly overcome the vaccine, and it may reinfect.” He compares the coronavirus to the flu or the common cold, which are constantly changing, dodging the body’s immune system. Gregory Armstrong told me of an experiment to determine how many mutations it would take to create what is known as an “immune escape” strain. “They grew it up in tissue culture from a generic sars-CoV-2 in dilute convalescent sera,” he said. “They were eventually able to grow one that had three mutations that conferred almost complete resistance” to the antibodies in the survivors’ blood.
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