The next variant: three key questions about what’s after Omicron

The next variant: three key questions about what’s after Omicron

This party isn't over.

"Although that has fed speculation that the virus could be evolving towards a strain that induces a milder disease, SARS-CoV-2’s evolutionary path remains unclear, says Rambaut. Thus far, new variants of concern have not evolved from the dominant preceding one. Instead, they have emerged from separate lineages. There is no guarantee that the next dominant variant will sprout from the ‘mild’ Omicron branch of the SARS-CoV-2 family tree. “It is possible that a later variant may be back to a Delta or Alpha lineage, with sufficient immune evasion to sweep Omicron away,” says Rambaut."